Andrew's ghost is a rather dangerous one, as he can perform a barrel roll that deals a great amount of damage, and also has a very strong aura that will damage Henry faster than any other ghost would. A Saint Medallion is required to weaken the evil presence, and a Silver Bullet is a great option to quickly pin him, followed shortly by a Sword of Obedience. It is recommended to pin him in the water wheel room, since it has a broader area for movement, and less enemies to annoy the player.
- When his ghost is encountered, Andrew can be heard singing: "And God said, 'At the time of fullness, cleanse the world with my rage. Gather forth the White Oil, the Black Cup and the Blood of the Ten Sinners. Prepare for the Ritual of the Holy Assumption.' And God said, 'Offer the Blood of the Ten Sinners and the White Oil.'"
- Due to his added girth, Andrew's ghost will be seen struggling out of his portal when he appears, until he finally slips out and starts floating.