Avary's career was launched through his friendship with famed writer and director Quentin Tarantino, with whom he made several films: Reservoir Dogs, Natural Born Killers, and Pulp Fiction. Avary also wrote and directed Killing Zoe and The Rules of Attraction. In 2007, Avary co-wrote Beowulf with Neil Gaiman.
On January 13, 2008, Avary was arrested on charges of manslaughter and DUI, due to a car crash in which his friend Andreas Zini was killed. He pleaded guilty to gross vehicular manslaughter and two felony counts of causing bodily injury while intoxicated, and was sentenced to one year in work furlough and five years probation. After eight months, Avary was released from prison.
Avary was hired in 2005 to write the scipt to Silent Hill, the big screen adaptation of the popular video game of the same name. He co-wrote the script with Christophe Gans and Nicolas Boukhrief. For reasons unknown, Avary was the only one of the three writers to receive a writing credit for the film.
Silent Hill: Revelation
Avary was asked to write the sequel to Silent Hill, the 2012 film Silent Hill: Revelation. In November of 2010, Avary was officially dropped from the film, and it was passed to Michael J. Bassett, who rewrote the script.