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The Piece of Hair is a puzzle item found in room S14 on the third floor of Brookhaven Hospital in Silent Hill 2. It can be obtained from a box by completing the Louise Puzzle, which is opened after unlocking all four locks.
The piece of hair is combined with a bent needle and used in a nearby shower room to fish out an elevator key from a drainage hole. This is an example of an abstract item being used for something other than its intended or obvious purpose, a trait which the series is known for.