The bottle of Oxydol is an obtainable item in Silent Hill 3. Heather Mason can find it immediately after confronting Vincent Smith in the Otherworld version of Hilltop Center in a broken cabinet. By using it in conjunction with the pork liver and matchbook, Heather creates a fire potent enough to burn a painting completely in the Gallery of Fine Arts section of the building.
- The painting burned using the oxydol has a caption that reads "flame purifies all", which refers to the burning of Alessa Gillespie discussed in the first game.
- Oxydol is a compound that is defined differently in Japan than in the United States:
- In Japan, "oxydol" is the medical term for a 3% hydrogen peroxide solution.
- In the US, "oxydol" refers to a type of laundry detergent.