They appear similar to their film counterpart, with very deformed and rather featureless faces, short, revealing dresses made of skin, and feet marked by heels. As well, the nurses engage in twitchy movements and an attraction to any source of light or a considerable level of sound, remaining frozen until alerted.
Nurses are usually rather easy enemies to overcome, and can be defeated using melee combos with the knife. Later on in the game, however, they get significantly more dangerous, being able to use incredibly quick slashes in rapid succession which makes approaching or even escaping them difficult. Turning off the flashlight will lower the chance of being attacked by a nurse, however this also hinders Alex as he is often plunged into complete darkness without it. Normally they are found in groups of three or more.
If the Nurse is stunned and Alex is wielding his knife, the finishing move shows Alex stabbing her twice in her breast and throwing her down to a pool of her own blood.
In this game, they represent Alex's institutionalization in the hospital, and his suppressed libido. More than this, however, they seem to be a nod to the film, which borrowed elements from Silent Hill 2. In the game, there are hints that Alex believed that the nurses in the military were overly sexualized to comfort the wounded soldiers. The fetuses they carry inside could also symbolize Alex's brother's birth.
- When the player kills the first nurse on the Xbox 360 version in the hospital, they will receive the achievement "Alchemilla's Finest."
- When radiated with the flashlight, one can see a fetus growing inside their wombs.