Nathan Drugs is a drug store found in the town of Silent Hill, West Virginia, making an appearance in the film.

Nathan Drugs is located beneath the apartment of Dahlia and Alessa Gillespie. Rose Da Silva passes it three times in the film, twice after meeting Dahlia, which means her daughter Sharon may be inside the last two times. Several cultists, along with Christabella, deduce that Dahlia has helped Sharon to hide in their old apartment, and capture Sharon and Dahlia, before taking them to the church. They intend for Sharon to be burned alive as a witch and for Dahlia to "bear witness" to the execution.