Alice's first film role was in Chariots of Fire, which she filmed at the age of 26. She later played Alma Mobley in Ghost Story, a character who inspired Alma Wade in the F.E.A.R. series. Alice won "Best Supporting Actress" at the Saturn Awards for her role as the Borg Queen in 1997. She then appeared in the horror film Sleepwalkers.
Alice was hired for the 2006 horror Silent Hill by director Christophe Gans, who felt she had the cold, tyrannical look he was looking for to play Christabella. Alice was the last person hired for the project, just two weeks before the start of filming. Alice did not particularly enjoy the role, feeling that her character was too manipulative and evil. To prepare for the role, Alice read books on the Spanish Inquisition.
- Alice wore blue contacts for Silent Hill, to match the eye color of Deborah Kara Unger and Jodelle Ferland, who played Christabella's relatives.
- Ironically, Alice's character Alma Mobley inspired Alma Wade, a character very similar to Silent Hill's Alessa Gillespie.
- Alice's personality was so dominant that other actors and extras responded to her commands on the set of Silent Hill.
|Radha Mitchell - Sean Bean - Laurie Holden - Deborah Kara Unger - Kim Coates - Tanya Allen - Alice Krige - Jodelle Ferland|
|Eve Crawford - Nicky Guadagni - Chris Britton - Roberto Campanella - Michael Cota - Yvonne Ng - Lorry Ayers - Emily Lineham|
|Samuel Hadida - Don Carmody - Victor Hadida - Nicolas Boukhrief - Deb LeFaive - Andrew Mason - Akira Yamaoka|
|Christophe Gans - Nicolas Boukhrief - Roger Avary|
|Jeff Danna - Akira Yamaoka|
|Dan Laustsen - Carol Spier - Wendy Partridge - Patrick Tatopoulos - Paul Jones|